题目：Constrained Total Variation Based Three-Dimension Single Particle Reconstruction in Cryogenic Electron Microscopy

报告人：潘欢（博士），湖南师范大学

摘要：

The Single Particle Reconstruction (SPR) in cryogenic electron mi- croscopy (cryo-EM) is considered in this paper. This is an emerging technique for determining the three-dimensional (3D) structure of biological specimens from a limited number of the micrographs. Because the micrographs are modulated by contrast transfer functions and corrupted by heavy noise, the number of micrographs might be limited, in general it is a serious ill-posed problem to reconstruct the original particle. In this paper, we propose a constrained total variation (TV) model for single particle reconstruction. The TV norm is represented by the dual formulation that changes the SPR problem into a minimax one. The primal-dual method is applied to find the saddle point of the minimax problem, and the con- vergence condition is given. Numerical results show that the proposed model is very effective in reconstructing the particle.

时间：11月27日（周三）13:50–14:50

地点：首师大新教二913

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检测成像北京市高校工程研究中心

北京成像理论与技术高精尖创新中心

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